In our recent question and also answer, the pharmacist discusses whether or no hydroxyzine can reason a false-positive because that benzodiazepines.

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cindy asked

Will a positive an outcome occur ~ above a 10 allude urine drug test as a benzodiazepine if you room taking hydroxyzine?

At a glance

Hydroxyzine is not known to reason false-positives for benzodiazepines on urine drug tests. However, it has been report to cause false-positives for an additional class that drugs, tricyclic antidepressants.



The inquiry of whether or no a particular drug or supplement can reason a false-positive on a urine drug screening is a typical one and a good one come ask.

The most frequently utilized tests are urine-based immunoassays, and they room subject come false positives. Researches that advice drugs linked with producing false-positive results frequently provide substantial lists. Because that example, the complying with have to be reported to cause false-positive because that opioids alone:

Poppy seeds

Immunoassay urine screenings are subject come false-positive based merely on exactly how the exam work:

antitoxin are used to tie to and also react v a specified compound (such as a benzodiazepine). Once an antibody finds the compound it is looking for and also binds to it; it produces a reaction. Such reactions are videotaped as a "positive" result.Unfortunately, there is a problem with "cross-reactivity". Drugs that are not being tested for deserve to occasionally react with the dorn antibody (i.e. "cross-react"), leading to a "false positive."

As friend are concerned with hydroxyzine, let"s take a look at that drug and also see if the is linked with creating false-positive on medicine tests.

What Is Hydroxyzine?


Hydroxyzine is a sedating first-generation antihistamine, structurally concerned meclizine.

It has very similar effects to Benadryl (diphenhydramine), another first-generation antihistamine, however they are technically in different medication class (hydroxyzine is a "piperazine" antihistamine while Benadryl is an "ethanolamine" antihistamine).

Hydroxyzine HCL Vs. Hydroxyzine Pamoate

Hydroxyzine is accessible as two various salt forms:

Atarax (hydroxyzine HCl)Vistaril (hydroxyzine pamoate)

There is rather a little of dispute concerning the different effects each salt form has. That is typically thought that Atarax is used more for itching and also Vistaril is used for anxiety and as a sedative.

While a particular individual may have slightly different effects v one or the other, most sources, including the prescribing info for both drugs, state they have near-identical pharmacokinetic profiles.

The onset of impact for both is around 15 come 60 minutes after acquisition a dose, and both last roughly 4 to 6 hours. Hydroxyzine pamoate may reason slightly much more sedation, however.

Does Hydroxyzine cause False Positives because that Benzodiazepines On medicine Tests?


Benzodiazepines are among the most generally prescribed drugs and are supplied for a wide selection of indications, including anxiety disorders, insomnia and as a muscle relaxant.

Drugs in the benzodiazepine class include:

While useful, benzodiazepines can cause physiologicaldependence and also have a risk of abuse and also misuse. Therefore, they are often had in drug screening tests.

Although there are reports of numerous drugs resulting in false-positives for benzodiazepines on drug tests (e.g., sertraline, oxaprozin),Hydroxyzine has actually not been associated with it. If you tested optimistic for a benzodiazepine recently on a urine-based medicine test, hydroxyzine likely was not the culprit.

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Nevertheless, hydroxyzine has been reported to reason a false confident for another course of drugs, tricyclic antidepressants, or TCAs.

One the the most frequently cited studies on urine drug screening, "Urine drug Screening: Practical overview for Clinicians ", claims the following regarding TCA false-positives: